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Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer

We engineered a disulfide-stabilized influenza virus hemagglutinin (HA) trimer, termed HA(3)-SS, by introducing cysteine residues into the HA stem to covalently bridge the three protomers. HA(3)-SS has increased thermostability compared to wild-type HA, and binding of head- and stem-targeted antibod...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Lee, Peter S., Zhu, Xueyong, Yu, Wenli, Wilson, Ian A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473583/
https://ncbi.nlm.nih.gov/pubmed/25926650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00808-15
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