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Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer
We engineered a disulfide-stabilized influenza virus hemagglutinin (HA) trimer, termed HA(3)-SS, by introducing cysteine residues into the HA stem to covalently bridge the three protomers. HA(3)-SS has increased thermostability compared to wild-type HA, and binding of head- and stem-targeted antibod...
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| Publicado no: | J Virol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4473583/ https://ncbi.nlm.nih.gov/pubmed/25926650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00808-15 |
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