A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface

Here we describe the discovery of a naturally occurring human antibody (Ab) FluA-20 that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and that reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 head domains revealed a novel epi...

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Publicado no:Cell
Main Authors: Bangaru, Sandhya, Lang, Shanshan, Schotsaert, Michael, Vanderven, Hillary A., Zhu, Xueyong, Kose, Nurgun, Bombardi, Robin, Finn, Jessica A, Kent, Stephen J., Gilchuk, Pavlo, Gilchuk, Iuliia, Turner, Hannah L., García-Sastre, Adolfo, Li, Sheng, Ward, Andrew B., Wilson, Ian A., Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629437/
https://ncbi.nlm.nih.gov/pubmed/31100268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.011
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