Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice

H7N9 avian influenza virus causes severe infections and might have the potential to trigger a major pandemic. Molecular determinants of human humoral immune response to N9 neuraminidase (NA) proteins, which exhibit unusual features compared with seasonal influenza virus NA proteins, are ill-defined....

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Veröffentlicht in:Cell Host Microbe
Hauptverfasser: Gilchuk, Iuliia M., Bangaru, Sandhya, Gilchuk, Pavlo, Irving, Ryan P., Kose, Nurgun, Bombardi, Robin G., Thornburg, Natalie J., Creech, C. Buddy, Edwards, Kathryn M., Li, Sheng, Turner, Hannah L., Yu, Wenli, Zhu, Xueyong, Wilson, Ian A., Ward, Andrew B., Crowe, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941661/
https://ncbi.nlm.nih.gov/pubmed/31757769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.10.003
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