EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion

The roles of EZH2 in various subsets of CD4(+) T cells are controversial and its mechanisms of action are incompletely understood. FOXP3-positive Treg cells are a critical helper T cell subset, and dysregulation of Treg generation or function results in systemic autoimmunity. FOXP3 associates with E...

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Vydáno v:Sci Rep
Hlavní autoři: Yang, Xiang-Ping, Jiang, Kan, Hirahara, Kiyoshi, Vahedi, Golnaz, Afzali, Behdad, Sciume, Giuseppe, Bonelli, Michael, Sun, Hong-Wei, Jankovic, Dragana, Kanno, Yuka, Sartorelli, Vittorio, O’Shea, John J., Laurence, Arian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473539/
https://ncbi.nlm.nih.gov/pubmed/26090605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10643
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