Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3

Mice reconstituted with a human immune system provide a tractable in vivo model to assess human immune cell function. To date, reconstitution of murine strains with human hematopoietic stem cells (HSCs) from patients with monogenic immune disorders have not been reported. One obstacle precluding the...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Goettel, Jeremy A., Biswas, Subhabrata, Lexmond, Willem S., Yeste, Ada, Passerini, Laura, Patel, Bonny, Yang, Siyoung, Sun, Jiusong, Ouahed, Jodie, Shouval, Dror S., McCann, Katelyn J., Horwitz, Bruce H., Mathis, Diane, Milford, Edgar L., Notarangelo, Luigi D., Roncarolo, Maria-Grazia, Fiebiger, Edda, Marasco, Wayne A., Bacchetta, Rosa, Quintana, Francisco J., Pai, Sung-Yun, Klein, Christoph, Muise, Aleixo M., Snapper, Scott B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473116/
https://ncbi.nlm.nih.gov/pubmed/25833964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-618363
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