Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3

Mice reconstituted with a human immune system provide a tractable in vivo model to assess human immune cell function. To date, reconstitution of murine strains with human hematopoietic stem cells (HSCs) from patients with monogenic immune disorders have not been reported. One obstacle precluding the...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Goettel, Jeremy A., Biswas, Subhabrata, Lexmond, Willem S., Yeste, Ada, Passerini, Laura, Patel, Bonny, Yang, Siyoung, Sun, Jiusong, Ouahed, Jodie, Shouval, Dror S., McCann, Katelyn J., Horwitz, Bruce H., Mathis, Diane, Milford, Edgar L., Notarangelo, Luigi D., Roncarolo, Maria-Grazia, Fiebiger, Edda, Marasco, Wayne A., Bacchetta, Rosa, Quintana, Francisco J., Pai, Sung-Yun, Klein, Christoph, Muise, Aleixo M., Snapper, Scott B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2015
Onderwerpen:
Immunobiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473116/
https://ncbi.nlm.nih.gov/pubmed/25833964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-618363
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