Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53

After treatment with ultraviolet radiation (UV), human fibroblasts that express the HPV type 16 E6 oncoprotein display defects in repair of cyclobutane pyrimidine dimers, hypersensitivity to inactivation of clonogenic survival and an inability to sustain DNA replication. To determine whether these e...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Chen, Bo, Simpson, Dennis A., Zhou, Yingchun, Mitra, Amritava, Mitchell, David L., Cordeiro-Stone, Marila, Kaufmann, William K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471864/
https://ncbi.nlm.nih.gov/pubmed/19411857
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