Polycystin-1 is a Cardiomyocyte Mechanosensor That Governs L-type Ca(2+) Channel Protein Stability

BACKGROUND: L-type calcium channel (LTCC) activity is critical to afterload-induced hypertrophic growth of the heart. However, mechanisms governing mechanical stress-induced activation of LTCC activity are obscure. Polycystin-1 (PC-1) is a G-protein-coupled receptor-like protein that functions as a...

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Veröffentlicht in:Circulation
Hauptverfasser: Pedrozo, Zully, Criollo, Alfredo, Battiprolu, Pavan K., Morales, Cyndi R., Contreras, Ariel, Fernández, Carolina, Jiang, Nan, Luo, Xiang, Caplan, Michael J., Somlo, Stefan, Rothermel, Beverly A., Gillette, Thomas G., Lavandero, Sergio, Hill, Joseph A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470854/
https://ncbi.nlm.nih.gov/pubmed/25888683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.013537
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