Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance

Staphylococcus aureus infections exert a tremendous burden on the health-care system, and the threat of drug-resistant strains continues to grow. The bacteriolytic enzyme lysostaphin is a potent antistaphylococcal agent with proven efficacy against both drug-sensitive and drug-resistant strains; how...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Blazanovic, Kristina, Zhao, Hongliang, Choi, Yoonjoo, Li, Wen, Salvat, Regina S, Osipovitch, Daniel C, Fields, Jennifer, Moise, Leonard, Berwin, Brent L, Fiering, Steven N, Bailey-Kellogg, Chris, Griswold, Karl E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470366/
https://ncbi.nlm.nih.gov/pubmed/26151066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.21
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