Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts

INTRODUCTION: Acetaminophen-cysteine adducts (APAP-CYS) are a serum biomarker of acetaminophen exposure, formed when the oxidative metabolite of acetaminophen binds to cysteine residues of hepatic proteins. APAP-CYS adducts become elevated in cases of acute liver failure following acetaminophen over...

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Veröffentlicht in:J Med Toxicol
Hauptverfasser: Frey, Sean M., Wiegand, Timothy J., Green, Jody L., Heard, Kennon J., Wilkins, Diana G., Gorodetsky, Rachel M., Dart, Richard C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2015
Schlagworte:
Toxicology Observation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469719/
https://ncbi.nlm.nih.gov/pubmed/25896948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13181-015-0476-x
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