Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose

Elevated concentrations of serum acetaminophen-protein adducts, measured as protein-derived acetaminophen-cysteine (APAP-CYS), have been used to support a diagnosis of APAP-induced liver injury when histories and APAP levels are unhelpful. Adducts have been reported to undergo first-order eliminatio...

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Bibliografske podrobnosti
izdano v:J Med Toxicol
Main Authors: Curry, Steven C., Padilla-Jones, Angela, O’Connor, Ayrn D., Ruha, Anne-Michelle, Bikin, Dale S., Wilkins, Diana G., Rollins, Douglas E., Slawson, Matthew H., Gerkin, Richard D.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2014
Teme:
Toxicology Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469721/
https://ncbi.nlm.nih.gov/pubmed/25288219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13181-014-0431-2
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