Aminopeptidase N Is a Receptor for Tumor-homing Peptides and a Target for Inhibiting Angiogenesis

Phage that display a surface peptide with the NGR sequence motif home selectively to tumor vasculature in vivo. A drug coupled to an NGR peptide has more potent antitumor effects than the free drug [W. Arap et al., Science (Washington DC), 279: 377–380, 1998]. We show here that the receptor for the...

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Publicat a:Cancer Res
Autors principals: Pasqualini, Renata, Koivunen, Erkki, Kain, Renate, Lahdenranta, Johanna, Sakamoto, Michiie, Stryhn, Anette, Ashmun, Richard A., Shapiro, Linda H., Arap, Wadih, Ruoslahti, Erkki
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469333/
https://ncbi.nlm.nih.gov/pubmed/10676659
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