Oral Administration of the Nucleoside EFdA (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Provides Rapid Suppression of HIV Viremia in Humanized Mice and Favorable Pharmacokinetic Properties in Mice and the Rhesus Macaque

Like normal cellular nucleosides, the nucleoside reverse transcriptase (RT) inhibitor (NRTI) 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) has a 3′-hydroxyl moiety, and yet EFdA is a highly potent inhibitor of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication with...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Stoddart, Cheryl A., Galkina, Sofiya A., Joshi, Pheroze, Kosikova, Galina, Moreno, Mary E., Rivera, Jose M., Sloan, Barbara, Reeve, Aaron B., Sarafianos, Stefan G., Murphey-Corb, Michael, Parniak, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468726/
https://ncbi.nlm.nih.gov/pubmed/25941222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05036-14
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