Intestinal Epithelium–Specific Knockout of the Cytochrome P450 Reductase Gene Exacerbates Dextran Sulfate Sodium–Induced Colitis

The potential involvement of intestinal microsomal cytochrome P450 (P450) enzymes in defending against colon inflammation and injury was studied in mice treated with dextran sulfate sodium (DSS) to induce colitis. Wild-type (WT) mice and mice with intestinal epithelium (IE)–specific deletion of the...

Full description

Saved in:
Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Zhu, Yi, Xie, Fang, Ding, Liang, Fan, Xiaoyu, Ding, Xinxin, Zhang, Qing-Yu
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468430/
https://ncbi.nlm.nih.gov/pubmed/25926522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.223263
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items