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Intestinal Epithelium–Specific Knockout of the Cytochrome P450 Reductase Gene Exacerbates Dextran Sulfate Sodium–Induced Colitis

The potential involvement of intestinal microsomal cytochrome P450 (P450) enzymes in defending against colon inflammation and injury was studied in mice treated with dextran sulfate sodium (DSS) to induce colitis. Wild-type (WT) mice and mice with intestinal epithelium (IE)–specific deletion of the...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Zhu, Yi, Xie, Fang, Ding, Liang, Fan, Xiaoyu, Ding, Xinxin, Zhang, Qing-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468430/
https://ncbi.nlm.nih.gov/pubmed/25926522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.223263
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