Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes

Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes during the development of obesity. However, it remains unclear whether palmitate directly impacts the circadian clock in...

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Vydáno v:PLoS One
Hlavní autoři: Tong, Xin, Zhang, Deqiang, Arthurs, Blake, Li, Pei, Durudogan, Leigh, Gupta, Neil, Yin, Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468094/
https://ncbi.nlm.nih.gov/pubmed/26075729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130047
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