Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models

BACKGROUND: Anti-glomerular basement membrane nephritis and Goodpasture syndrome result from autoantibody (Ab)-mediated destruction of kidney and lung. Ab target the noncollagenous 1 (NC1) domain of alpha3(IV) collagen, but little is known about Ab origins or structure. This ignorance is due in part...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Worni-Schudel, Inge M, Clark, Amy G, Chien, Tiffany, Hwang, Kwan-Ki, Chen, Benny J, Foster, Mary H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467618/
https://ncbi.nlm.nih.gov/pubmed/26048777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0539-4
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