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Uncommon Structural Motifs Dominate the Antigen Binding Site in Human Autoantibodies Reactive with Basement Membrane Collagen

Autoantibodies mediate organ destruction in multiple autoimmune diseases, yet their origins in patients remain poorly understood. To probe the genetic origins and structure of disease-associated autoantibodies, we engrafted immunodeficient mice with human CD34+ hematopoietic stem cells and immunized...

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Detalles Bibliográficos
Publicado en:Mol Immunol
Main Authors: Foster, Mary H., Buckley, Elizabeth S., Chen, Benny J., Hwang, Kwan-Ki, Clark, Amy G.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979994/
https://ncbi.nlm.nih.gov/pubmed/27450516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2016.07.004
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