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Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo

α1(IV)NC1 inhibits angiogenesis by regulating MAPK activation, this biological function was partly attributed α1(IV)NC1 binding to α1β1-integrin. However, its potent antiangiogenic activity and the molecular targets of α1(IV)NC1 has not been investigated. In the present study, the regulation of MMP-...

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מידע ביבליוגרפי
Main Authors: Sudhakar, Yakkanti Akul, Verma, Raj Kumar, Pawar, Smita C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966261/
https://ncbi.nlm.nih.gov/pubmed/24670518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04136
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