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Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo
α1(IV)NC1 inhibits angiogenesis by regulating MAPK activation, this biological function was partly attributed α1(IV)NC1 binding to α1β1-integrin. However, its potent antiangiogenic activity and the molecular targets of α1(IV)NC1 has not been investigated. In the present study, the regulation of MMP-...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3966261/ https://ncbi.nlm.nih.gov/pubmed/24670518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04136 |
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