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Somatic mutations in glioblastoma are associated with methylguanine-DNA methyltransferase methylation
The high level of methylguanine-DNA methyltransferase (MGMT) in glioblastoma is responsible for resistance to alkylating agents, such as temozolomide (TMZ). In glioblastomas with a methylated MGMT promoter, MGMT deficiency is presumed, resulting in an enhanced effect of TMZ. The aim of the present s...
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| Yayımlandı: | Oncol Lett |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
D.A. Spandidos
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467216/ https://ncbi.nlm.nih.gov/pubmed/26137013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2015.2980 |
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