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Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes

Variety of HIV-1 viral proteins including HIV-1 Nef are known to activate astrocytes and microglia in the brain and cause the release of pro-inflammatory cytokines, which is thought to be one of the mechanisms leading to HIV-1- mediated neurotoxicity. IL-6 and IL-8 have been found in the CSF of pati...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Liu, Xun, Kumar, Anil
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467202/
https://ncbi.nlm.nih.gov/pubmed/26075907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09867
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