The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

The heparan sulfate mimetic PG545 has been shown to exert anti-angiogenic and anti-metastatic activity in vitro and in vivo cancer models. Although much of this activity has been attributed to inhibition of heparanase and heparan sulfate-binding growth factors, it was hypothesized that PG545 may add...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Jung, Deok-Beom, Yun, Miyong, Kim, Eun-Ok, Kim, Jaekwang, Kim, Bonglee, Jung, Ji Hoon, Wang, Enfeng, Mukhopadhyay, Debabrata, Hammond, Edward, Dredge, Keith, Shridhar, Viji, Kim, Sung-Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467129/
https://ncbi.nlm.nih.gov/pubmed/25669977
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