The Heparan Sulfate Mimetic PG545 Modulates T Cell Responses and Prevents Delayed-Type Hypersensitivity

The heparan sulfate mimetic PG545 (pixatimod) is under evaluation as an inhibitor of angiogenesis and metastasis including in human clinical trials. We have examined the effects of PG545 on lymphocyte phenotypes and function. We report that PG545 treatment suppresses effector T cell activation and p...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Koliesnik, Ievgen O., Kuipers, Hedwich F., Medina, Carlos O., Zihsler, Svenja, Liu, Dan, Van Belleghem, Jonas D., Bollyky, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015948/
https://ncbi.nlm.nih.gov/pubmed/32117279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00132
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