Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation

Heparan sulfate (HS) is an essential component of the extracellular matrix (ECM), which serves as a barrier to tumor invasion and metastasis. Heparanase promotes tumor growth by cleaving HS chains of proteoglycan and releasing HS-bound angiogenic growth factors and facilitates tumor invasion and met...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Brennan, Todd V., Lin, Liwen, Brandstadter, Joshua D., Rendell, Victoria R., Dredge, Keith, Huang, Xiaopei, Yang, Yiping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701545/
https://ncbi.nlm.nih.gov/pubmed/26649979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76566
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