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Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues()
The tetrasaccharide heparan sulfate (HS) mimetic PG545, a clinical anti-cancer candidate, is an inhibitor of the HS-degrading enzyme heparanase. The kinetics of heparanase inhibition by PG545 and three structural analogues were investigated to understand their modes of inhibition. The cholestanol ag...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821029/ https://ncbi.nlm.nih.gov/pubmed/24251094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2013.07.007 |
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