JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer*

Amplification and overexpression of c-Myc is commonly seen in human ovarian cancers, and this could be a potentially novel therapeutic target for this disease. JQ1, a selective small-molecule BET bromodomain (BRDs) inhibitor, has been found to suppress tumor progression in several cancer cell types....

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Pubblicato in:Oncotarget
Autori principali: Qiu, Haifeng, Jackson, Amanda L., Kilgore, Joshua E., Zhong, Yan, Chan, Leo Li-Ying, Gehrig, Paola A., Zhou, Chunxiao, Bae-Jump, Victoria L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466659/
https://ncbi.nlm.nih.gov/pubmed/25762632
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