JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer

Overexpression of c-Myc is associated with worse outcomes in endometrial cancer, indicating that c-Myc may be a promising target for endometrial cancer therapy. A novel small molecule, JQ1, has been shown to block BRD4 resulting in inhibition of c-Myc expression and tumor growth. Thus, we investigat...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Qiu, Haifeng, Li, Jing, Clark, Leslie H., Jackson, Amanda L., Zhang, Lu, Guo, Hui, Kilgore, Joshua E., Gehrig, Paola A., Zhou, Chunxiao, Bae-Jump, Victoria L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341839/
https://ncbi.nlm.nih.gov/pubmed/27572308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11631
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