AMG 479, a Novel IGF-1-R Antibody, Inhibits Endometrial Cancer Cell Proliferation Through Disruption of the PI3K/Akt and MAPK Pathways

Our goal was to evaluate the therapeutic potential of a novel antibody to the insulin growth factor-1 receptor (IGF-1-R; AMG 479) in endometrial cancer cells. The endometrial cancer cell lines, ECC-1/PRAB72 and RL-95-2, were used. Treatment with AMG 479 (0.02-200 nmol/L) resulted in inhibition of ce...

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Main Authors: Mendivil, Albert, Zhou, Chunxiao, Cantrell, Leigh A., Gehrig, Paola A., Malloy, Kim M., Blok, Leen J., Burger, Curt W., Bae-Jump, Victoria L.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046305/
https://ncbi.nlm.nih.gov/pubmed/21846689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1933719111398501
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