NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo

BACKGROUND: NT1014 is a novel biguanide and AMPK activator with a high affinity for the organic cation-specific transporters, OCT1 and OCT3. We sought to determine the anti-tumorigenic effects of NT1014 in human ovarian cancer cell lines as well as in a genetically engineered mouse model of high-gra...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Zhang, Lu, Han, Jianjun, Jackson, Amanda L., Clark, Leslie N., Kilgore, Joshua, Guo, Hui, Livingston, Nick, Batchelor, Kenneth, Yin, Yajie, Gilliam, Timothy P., Gehrig, Paola A., Sheng, Xiugui, Zhou, Chunxiao, Bae-Jump, Victoria L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031332/
https://ncbi.nlm.nih.gov/pubmed/27655410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0325-7
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