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Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer

Obesity and diabetes have been associated with increased risk and worse outcomes in ovarian cancer (OC). The biguanide metformin is used in the treatment of type 2 diabetes and is also believed to have anti-tumorigenic benefits. Metformin is highly hydrophilic and requires organic cation transporter...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jackson, Amanda L., Sun, Wenchuan, Kilgore, Joshua, Guo, Hui, Fang, Ziwei, Yin, Yajie, Jones, Hannah M., Gilliam, Timothy P., Zhou, Chunxiao, Bae-Jump, Victoria L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725006/
https://ncbi.nlm.nih.gov/pubmed/29245964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22012
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