Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer

Obesity and diabetes have been associated with increased risk and worse outcomes in ovarian cancer (OC). The biguanide metformin is used in the treatment of type 2 diabetes and is also believed to have anti-tumorigenic benefits. Metformin is highly hydrophilic and requires organic cation transporter...

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Vydáno v:Oncotarget
Hlavní autoři: Jackson, Amanda L., Sun, Wenchuan, Kilgore, Joshua, Guo, Hui, Fang, Ziwei, Yin, Yajie, Jones, Hannah M., Gilliam, Timothy P., Zhou, Chunxiao, Bae-Jump, Victoria L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725006/
https://ncbi.nlm.nih.gov/pubmed/29245964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22012
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