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Enzyme Replacement for Craniofacial Skeletal Defects and Craniosynostosis in Murine Hypophosphatasia
Hypophosphatasia (HPP) is an inborn-error-of-metabolism disorder characterized by deficient bone and tooth mineralization due to loss-of function mutations in the gene (Alpl) encoding tissue-nonspecific alkaline phosphatase (TNAP). Alpl(−/−) mice exhibit many characteristics seen in infantile HPP in...
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| Publicat a: | Bone |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4466206/ https://ncbi.nlm.nih.gov/pubmed/25959417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.05.005 |
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