Construction and Immunogenicity Evaluation of Recombinant Influenza A Viruses Containing Chimeric Hemagglutinin Genes Derived from Genetically Divergent Influenza A H1N1 Subtype Viruses

BACKGROUND AND OBJECTIVES: Influenza A viruses cause highly contagious diseases in a variety of hosts, including humans and pigs. To develop a vaccine that can be broadly effective against genetically divergent strains of the virus, in this study we employed molecular breeding (DNA shuffling) techno...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: McCormick, Kara, Jiang, Zhiyong, Zhu, Longchao, Lawson, Steven R., Langenhorst, Robert, Ransburgh, Russell, Brunick, Colin, Tracy, Miranda C., Hurtig, Heather R., Mabee, Leah M., Mingo, Mark, Li, Yanhua, Webby, Richard J., Huber, Victor C., Fang, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465703/
https://ncbi.nlm.nih.gov/pubmed/26061265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127649
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