Immunogenicity and efficacy of replication-competent recombinant influenza virus carrying multimeric M2 extracellular domains in a chimeric hemagglutinin conjugate

Current influenza vaccines provide hemagglutinin (HA) strain-specific protection. To improve cross protection, we engineered replication-competent influenza A virus to express tandem repeats of heterologous M2 extracellular (M2e) domains in a chimeric HA. M2e epitopes conjugated to HA glycoproteins...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: Kim, Min-Chul, Lee, Yu-Na, Kim, Yu-Jin, Choi, Hyo-Jick, Kim, Ki-Hye, Lee, Youn-Jeong, Kang, Sang-Moo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699712/
https://ncbi.nlm.nih.gov/pubmed/29107058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.10.018
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