Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway

Atherosclerotic lesions are accelerated in patients with diabetes. M1 (classically activated in contrast to M2 alternatively activated) macrophages play key roles in the progression of atherosclerosis. Since advanced glycation end products (AGEs) are major pathogenic factors and active inflammation...

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Veröffentlicht in:Biomed Res Int
Hauptverfasser: Jin, Xian, Yao, Tongqing, Zhou, Zhong'e, Zhu, Jian, Zhang, Song, Hu, Wei, Shen, Chengxing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465680/
https://ncbi.nlm.nih.gov/pubmed/26114112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/732450
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