Design, Synthesis and Biological Evaluation of Di-substituted Noscapine Analogs as Potent and Microtubule-Targeted Anticancer Agents

Noscapine is an opium-derived kinder-gentler microtubule-modulating drug, currently in Phase I/II clinical trials for cancer chemotherapy. Here, we report the synthesis of four more potent di-substituted brominated derivatives of noscapine, 9-Br-7-OH-NOS (2), 9-Br-7-OCONHEt-NOS (3), 9-Br-7-OCONHBn-N...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Bioorg Med Chem Lett
Главные авторы: Mishra, Ram C., Gundala, Sushma R., Karna, Prasanthi, Lopus, Manu, Gupta, Kamlesh K., Nagaraju, Mulpuri, Hamelberg, Donald, Tandon, Vibha, Panda, Dulal, Reid, Michelle D., Aneja, Ritu
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465564/
https://ncbi.nlm.nih.gov/pubmed/25891106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.076
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы