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Design, Synthesis and Biological Evaluation of Di-substituted Noscapine Analogs as Potent and Microtubule-Targeted Anticancer Agents

Noscapine is an opium-derived kinder-gentler microtubule-modulating drug, currently in Phase I/II clinical trials for cancer chemotherapy. Here, we report the synthesis of four more potent di-substituted brominated derivatives of noscapine, 9-Br-7-OH-NOS (2), 9-Br-7-OCONHEt-NOS (3), 9-Br-7-OCONHBn-N...

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מידע ביבליוגרפי
הוצא לאור ב:	Bioorg Med Chem Lett
Main Authors:	Mishra, Ram C., Gundala, Sushma R., Karna, Prasanthi, Lopus, Manu, Gupta, Kamlesh K., Nagaraju, Mulpuri, Hamelberg, Donald, Tandon, Vibha, Panda, Dulal, Reid, Michelle D., Aneja, Ritu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2015
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4465564/ https://ncbi.nlm.nih.gov/pubmed/25891106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.076
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Design, Synthesis and Biological Evaluation of Di-substituted Noscapine Analogs as Potent and Microtubule-Targeted Anticancer Agents

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