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Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase

BACKGROUND: Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed as a putative mechanism driving tolerance to...

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Foilsithe in:Mol Pain
Main Authors: Marcus, David J., Zee, Michael, Hughes, Alex, Yuill, Matthew B., Hohmann, Andrea G., Mackie, Ken, Guindon, Josée, Morgan, Daniel J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465461/
https://ncbi.nlm.nih.gov/pubmed/26065412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0031-4
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