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Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase
BACKGROUND: Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed as a putative mechanism driving tolerance to...
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| Опубликовано в: : | Mol Pain |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465461/ https://ncbi.nlm.nih.gov/pubmed/26065412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0031-4 |
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