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Change in functional selectivity of morphine with the development of antinociceptive tolerance
BACKGROUND AND PURPOSE: Opioids, such as morphine, are the most effective treatment for pain but their efficacy is diminished with the development of tolerance following repeated administration. Recently, we found that morphine activated ERK in opioid-tolerant but not in naïve rats, suggesting that...
Shranjeno v:
| izdano v: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Publishing Ltd
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292967/ https://ncbi.nlm.nih.gov/pubmed/24666417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12703 |
| Oznake: |
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