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Change in functional selectivity of morphine with the development of antinociceptive tolerance
BACKGROUND AND PURPOSE: Opioids, such as morphine, are the most effective treatment for pain but their efficacy is diminished with the development of tolerance following repeated administration. Recently, we found that morphine activated ERK in opioid-tolerant but not in naïve rats, suggesting that...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292967/ https://ncbi.nlm.nih.gov/pubmed/24666417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12703 |
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