c-Jun N terminal kinase signaling pathways mediate cannabinoid tolerance in an agonist-specific manner

Tolerance to the antinociceptive effects of cannabinoids represents a significant limitation to their clinical use in managing chronic pain. Tolerance likely results from desensitization and down-regulation of the cannabinoid type 1 receptor (CB(1)R), with CB(1)R desensitization occurring via phosph...

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Publicado no:Neuropharmacology
Main Authors: Henderson-Redmond, Angela N., Nealon, Caitlin M., Davis, Brian J., Yuill, Matthew B., Sepulveda, Diana E., Blanton, Henry L., Piscura, Mary K., Zee, Michael L., Haskins, Chris P., Marcus, David J., Mackie, Ken, Guindon, Josée, Morgan, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190707/
https://ncbi.nlm.nih.gov/pubmed/31758947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107847
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