c-Jun N terminal kinase signaling pathways mediate cannabinoid tolerance in an agonist-specific manner

Tolerance to the antinociceptive effects of cannabinoids represents a significant limitation to their clinical use in managing chronic pain. Tolerance likely results from desensitization and down-regulation of the cannabinoid type 1 receptor (CB(1)R), with CB(1)R desensitization occurring via phosph...

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Pubblicato in:Neuropharmacology
Autori principali: Henderson-Redmond, Angela N., Nealon, Caitlin M., Davis, Brian J., Yuill, Matthew B., Sepulveda, Diana E., Blanton, Henry L., Piscura, Mary K., Zee, Michael L., Haskins, Chris P., Marcus, David J., Mackie, Ken, Guindon, Josée, Morgan, Daniel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190707/
https://ncbi.nlm.nih.gov/pubmed/31758947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107847
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