A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion ()

Efforts to identify host determinants for malaria have been hindered by the absence of a nucleus in erythrocytes, precluding genetic manipulation in the cell where the parasite replicates. We used cultured red blood cells derived from hematopoietic stem cells to carry out a forward genetic screen fo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Science
Autores principales: Egan, Elizabeth S., Jiang, Rays H.Y., Moechtar, Mischka A., Barteneva, Natasha S., Weekes, Michael P., Nobre, Luis V., Gygi, Steven P., Paulo, Joao A., Frantzreb, Charles, Tani, Yoshihiko, Takahashi, Junko, Watanabe, Seishi, Goldberg, Jonathan, Paul, Aditya S., Brugnara, Carlo, Root, David E., Wiegand, Roger C., Doench, John G., Duraisingh, Manoj T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465434/
https://ncbi.nlm.nih.gov/pubmed/25954012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3526
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares