A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion ()

Efforts to identify host determinants for malaria have been hindered by the absence of a nucleus in erythrocytes, precluding genetic manipulation in the cell where the parasite replicates. We used cultured red blood cells derived from hematopoietic stem cells to carry out a forward genetic screen fo...

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Veröffentlicht in:Science
Hauptverfasser: Egan, Elizabeth S., Jiang, Rays H.Y., Moechtar, Mischka A., Barteneva, Natasha S., Weekes, Michael P., Nobre, Luis V., Gygi, Steven P., Paulo, Joao A., Frantzreb, Charles, Tani, Yoshihiko, Takahashi, Junko, Watanabe, Seishi, Goldberg, Jonathan, Paul, Aditya S., Brugnara, Carlo, Root, David E., Wiegand, Roger C., Doench, John G., Duraisingh, Manoj T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465434/
https://ncbi.nlm.nih.gov/pubmed/25954012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa3526
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