Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum

The ATP-binding cassette transporter ABCB6 was recently discovered to encode the Langereis (Lan) blood group antigen. Lan null individuals are asymptomatic, and the function of ABCB6 in mature erythrocytes is not understood. Here, we assessed ABCB6 as a host factor for Plasmodium falciparum malaria...

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Udgivet i:Commun Biol
Main Authors: Egan, Elizabeth S., Weekes, Michael P., Kanjee, Usheer, Manzo, Jale, Srinivasan, Ashwin, Lomas-Francis, Christine, Westhoff, Connie, Takahashi, Junko, Tanaka, Mitsunobu, Watanabe, Seishi, Brugnara, Carlo, Gygi, Steven P., Tani, Yoshihiko, Duraisingh, Manoj T.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123700/
https://ncbi.nlm.nih.gov/pubmed/30271928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0046-2
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