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New tricks for p53 regulation – restraint by protein coding RNAs

P53 is most well-known for its tumor suppressive function in differentiated cells. Its activities in embryonic stem cells (ESCs) are, however, less well understood. For many years it was thought that p53 is not active at all in ESCs and unable to elicit a DNA damage response in this cell type. In th...

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Publicat a:Cell Biosci
Autor principal: Blattner, Christine
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465304/
https://ncbi.nlm.nih.gov/pubmed/26075053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-015-0022-1
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