Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Chromosomal deletions associated with human diseases, such as cancer are common, but synteny issues complicate modeling of these deletions in mice. We use cellular reprogramming and genome engineering to functionally dissect the loss of chromosome 7q [del(7q)], a somatic cytogenetic abnormality pres...

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Bibliografiset tiedot
Julkaisussa:Nat Biotechnol
Päätekijät: Kotini, Andriana G, Chang, Chan-Jung, Boussaad, Ibrahim, Delrow, Jeffrey J, Dolezal, Emily K, Nagulapally, Abhinav B, Perna, Fabiana, Fishbein, Gregory A, Klimek, Virginia M, Hawkins, R David, Huangfu, Danwei, Murry, Charles E, Graubert, Timothy, Nimer, Stephen D, Papapetrou, Eirini P
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464949/
https://ncbi.nlm.nih.gov/pubmed/25798938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3178
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