Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

BACKGROUND: Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic tumor-associated antigen that is overexpressed on renal cell carcinoma (RCC). Therapeutic approaches targeting CAIX have focused on the developm...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Chang, De-Kuan, Moniz, Raymond J., Xu, Zhongyao, Sun, Jiusong, Signoretti, Sabina, Zhu, Quan, Marasco, Wayne A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464115/
https://ncbi.nlm.nih.gov/pubmed/26062742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0384-3
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