Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model

Recent studies have demonstrated that regulatory T cells (Tregs) are recruited to tumor sites where they can suppress antitumor immunity. The chemokine receptor CCR4 is expressed at high levels on functional CD4(+)CD25(+)FoxP3(+) Tregs and production of the CCR4 ligand CCL22 by tumor cells and tumor...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Chang, De-Kuan, Peterson, Eric, Sun, Jiusong, Goudie, Calum, Drapkin, Ronny I., Liu, Joyce F., Matulonis, Ursula, Zhu, Quan, Marasco, Wayne A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839340/
https://ncbi.nlm.nih.gov/pubmed/27141347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1090075
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